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  • Guideline Summary
  • NGC:008525
  • 2011 Jan 18

Best evidence statement (BESt). Oxygen versus air nebulization among pediatric patients with wheezing.

Cincinnati Children's Hospital Medical Center. Best evidence statement (BESt). Oxygen versus air nebulization pediatric patients with wheezing. Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2011 Jan 18. 4 p. [20 references]

View the original guideline documentation External Web Site Policy

This is the current release of the guideline.

Major Recommendations

There was insufficient evidence and lack of consensus to make a recommendation on the use of air or oxygen to deliver nebulized medication for pediatric patients who are wheezing or have asthma.

Clinical Algorithm(s)

None provided

Disease/Condition(s)

  • Wheezing
  • Asthma

Guideline Category

Treatment

Clinical Specialty

Allergy and Immunology

Family Practice

Pediatrics

Pulmonary Medicine

Intended Users

Advanced Practice Nurses

Nurses

Physician Assistants

Physicians

Guideline Objective(s)

To evaluate if, among pediatric patients with wheezing, the use of nebulizer with oxygen versus the use of air nebulizer for delivery of medication increases the improvement of respiratory symptoms as measured by respiratory score

Target Population

Pediatric patients with wheezing 0 to 18 years of age

Interventions and Practices Considered

Nebulizer with oxygen versus the use of air nebulizer for the delivery of medication

Major Outcomes Considered

Respiratory symptoms as measured by respiratory score

Methods Used to Collect/Select the Evidence

Searches of Electronic Databases

Description of Methods Used to Collect/Select the Evidence

Search Strategy

  • Databases searched: OVID MEDLINE, EBSCO CINAHL, PUBMED, SCOPUS, and GOOGLE SCHOLAR
  • Search Terms: Oxygen/air nebulizer, respiratory treatments, nebulizer/air, oxygen/albuterol, nebulizer therapy, asthma/therapy, asthma, oxygen
  • Filters: English language
  • Date range: All dates up to and including 4/2010

Number of Source Documents

Not stated

Methods Used to Assess the Quality and Strength of the Evidence

Weighting According to a Rating Scheme (Scheme Given)

Rating Scheme for the Strength of the Evidence

Table of Evidence Levels

Quality Level Definition
1a† or 1b† Systematic review, meta-analysis, or meta-synthesis of multiple studies
2a or 2b Best study design for domain
3a or 3b Fair study design for domain
4a or 4b Weak study design for domain
5 Other: General review, expert opinion, case report, consensus report, or guideline

†a = good quality study; b = lesser quality study

Methods Used to Analyze the Evidence

Review of Published Meta-Analyses

Systematic Review

Description of the Methods Used to Analyze the Evidence

Not stated

Methods Used to Formulate the Recommendations

Expert Consensus

Description of Methods Used to Formulate the Recommendations

Not stated

Rating Scheme for the Strength of the Recommendations

Table of Recommendation Strength

Strength Definition
"Strongly recommended" There is consensus that benefits clearly outweigh risks and burdens (or vice-versa for negative recommendations).
"Recommended" There is consensus that benefits are closely balanced with risks and burdens.
No recommendation made There is lack of consensus to direct development of a recommendation.
Dimensions: In determining the strength of a recommendation, the development group makes a considered judgment in a consensus process that incorporates critically appraised evidence, clinical experience, and other dimensions as listed below.
  1. Grade of the Body of Evidence (see note above)
  2. Safety/Harm
  3. Health benefit to the patients (direct benefit)
  4. Burden to patient of adherence to recommendation (cost, hassle, discomfort, pain, motivation, ability to adhere, time)
  5. Cost-effectiveness to healthcare system (balance of cost/savings of resources, staff time, and supplies based on published studies or onsite analysis)
  6. Directness (the extent to which the body of evidence directly answers the clinical question [population/problem, intervention, comparison, outcome])
  7. Impact on morbidity/mortality or quality of life

Cost Analysis

A formal cost analysis was not performed and published cost analyses were not reviewed.

Method of Guideline Validation

Peer Review

Description of Method of Guideline Validation

Reviewed against quality criteria by 2 independent reviewers.

Type of Evidence Supporting the Recommendations

Current evidence was found to be mostly expert opinion or descriptive studies, which was considered insufficient to make a recommendation.

Potential Benefits

Appropriate use of air or oxygen to deliver nebulized medications for pediatric patients who are wheezing or have asthma

Potential Harms

Not stated

Qualifying Statements

This Best Evidence Statement addresses only key points of care for the target population; it is not intended to be a comprehensive practice guideline. These recommendations result from review of literature and practices current at the time of their formulation. This Best Evidence Statement does not preclude using care modalities proven efficacious in studies published subsequent to the current revision of this document. This document is not intended to impose standards of care preventing selective variances from the recommendations to meet the specific and unique requirements of individual patients. Adherence to this Statement is voluntary. The clinician in light of the individual circumstances presented by the patient must make the ultimate judgment regarding the priority of any specific procedure.

Description of Implementation Strategy

An implementation strategy was not provided.

IOM Care Need

Getting Better

Living with Illness

IOM Domain

Effectiveness

Bibliographic Source(s)

Cincinnati Children's Hospital Medical Center. Best evidence statement (BESt). Oxygen versus air nebulization pediatric patients with wheezing. Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2011 Jan 18. 4 p. [20 references]

Adaptation

Not applicable: The guideline was not adapted from another source.

Date Released

2011 Jan 18

Guideline Developer(s)

Cincinnati Children's Hospital Medical Center - Hospital/Medical Center

Source(s) of Funding

Cincinnati Children's Hospital Medical Center

Guideline Committee

Not stated

Composition of Group That Authored the Guideline

Group/Team Members

Team Leader: Tricia Luckhaupt, RNII, CPN

Support Personnel: Lisa English Long, MSN, RN, CNS, Evidence based Mentor and Barbara K. Giambra, MS, RN, CPNP, Evidence based Practice Mentor, Center for Professional Excellence/Research and Evidence based Practice

Financial Disclosures/Conflicts of Interest

Not stated

Guideline Status

This is the current release of the guideline.

Guideline Availability

Electronic copies: Available from the Cincinnati Children's Hospital Medical Center External Web Site Policy.

Print copies: For information regarding the full-text guideline, print copies, or evidence-based practice support services contact the Cincinnati Children's Hospital Medical Center Health James M. Anderson Center for Health Systems Excellence at EBDMInfo@cchmc.org.

Availability of Companion Documents

The following are available:

Print copies: For information regarding the full-text guideline, print copies, or evidence-based practice support services contact the Cincinnati Children's Hospital Medical Center Health James M. Anderson Center for Health Systems Excellence at EBDMInfo@cchmc.org.

Patient Resources

None available

NGC Status

This NGC summary was completed by ECRI Institute on August 25, 2011.

Copyright Statement

This NGC summary is based on the original full-text guideline, which is subject to the following copyright restrictions:

Copies of this Cincinnati Children's Hospital Medical Center (CCHMC) External Web Site Policy Best Evidence Statement (BESt) are available online and may be distributed by any organization for the global purpose of improving child health outcomes. Examples of approved uses of the BESt include the following:

  • Copies may be provided to anyone involved in the organization's process for developing and implementing evidence based care
  • Hyperlinks to the CCHMC website may be placed on the organization's website
  • The BESt may be adopted or adapted for use within the organization, provided that CCHMC receives appropriate attribution on all written or electronic documents
  • Copies may be provided to patients and the clinicians who manage their care

Notification of CCHMC at EBDMInfo@cchmc.org for any BESt adopted, adapted, implemented or hyperlinked by the organization is appreciated.

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